2018年10月4日 星期四

Continuous Non Invasive Blood Pressure Research Platform (ECG and PPG) Pulse Arrival Time Based

This project is cuffless cNIBP research platform with ECG(two-electrode) and PPG

In cuffless non-invasive blood pressure monitor field, we with the accurate calibration of PAT to BP, beat-to-beat BP can be estimated from PAT. On the basis of the theoretical relationship between PAT and BP and their experimental or empirical relationship, various models that correlate PAT with BP have been established.

PAT and BP with Regression:

Pulse transit time (PTT) is the time it takes for the pressure or flow wave to propagate between two arterial sites. PTT measured as the time delay between invasive proximal and distal blood pressure or flow, and PTT(propagate time) can be converted to Pulse Wave Velocity(PWV is speed unit).
the most used is the R-wave(QRS Complex) in the electrocardiogram (ECG) and combine pulsemeter(piezo or PPG), leading to the so called pulse arrival time (PAT). PAT is not exactly the PTT, as it includes the time interval between ventricular depolarization and the opening of the aortic valve which is known as pre-ejection period (PEP) and it varies beat-to-beat.

Most efforts have employed the time delay between ECG and finger photoplethysmography (PPG) waveforms as a convenient surrogate of PTT.

However, these conventional pulse arrival time (PAT) measurements include the pre-ejection period (PEP) and the time delay through small, muscular arteries and may thus be an unreliable marker of BP.

Shortcoming is that PAT includes the pre-ejection period (PEP) in addition to PTT. Since the PEP component depends on the electromechanical functioning of the heart, it can change independently of PTT and thus BP.

Because the ECG QRS-Complex is not the starting point for blood to actually enter the radial artery, it is a biopotential to depolarization of the sinus node

This project only for research

Reference : 
[1] Continuous Blood Pressure Measurement from Invasive to Unobtrusive: Celebration of 200th Birth Anniversary of Carl Ludwig
[2] Cuff-Less and Continuous Blood Pressure Monitoring: A Methodological Review